ISOLATION, STRUCTURAL DETERMINATION, AND CYTOTOXICITY OF COMPOUNDS FROM THE NON-ALKALOID EXTRACT OF CINNAMOMUM BEJOLGHOTA

Tóm tắt

Eight compounds were isolated from the non-alkaloid extract of Cinnamomum bejolghota stem bark. Their chemical structures were elucidated as ergosta-4,6,8(14),22-tetraen-3-one (1), spathulenol (2), 5,7-dimethoxy-3',4'-methylenedioxyflavan-3-ol (3), afzelin (4), 3,4-dimethoxycinnamyl alcohol (5), 3,4-dimethoxycinnamaldehyde (6), veratraldehyde (7), and veratric acid (8) on the basis of detailed analysis of the 1D and 2D NMR spectroscopic data in comparison with the literature data. Compound 1 showed activity against the HepG-2 cell line with an IC₅₀ value of 21.8 µM. Compound 3 showed weak cytotoxic activity against KB, MCF-7, HepG-2, and SK-LU-1 human cancer cell lines with IC₅₀ values of 118.3, 110.7, 90.2, and 95.8 µM, respectively. Compounds 1 and 4 were reported from this plant for the first time.