ISOLATION, STRUCTURAL DETERMINATION OF FLAVONE GLYCOSIDES FROM THE LEAVES OF SYZYGIUM CUMINI AND THEIR CYTOTOXIC EVALUATION

Tóm tắt

Five flavone glycosides were isolated from the EtOAc and aqueous extracts of Syzygium cumini (L.) Skeels leaves. Their chemical structures were elucidated as quercetin 3-O-neohesperidoside (1), rutin (2), quercetin 3-O-α-L-rhamnopyranoside (3), kaempferol 3-O-neohesperidoside (4), and afzelin (5) on the basis of detailed analyses of the 1D and 2D NMR spectroscopic data and in comparison with the literature data. All isolated compounds (1-5) were estimated for their cytotoxicity against KB, MCF-7, HepG2, and A549 human cancer cell lines. Unfortunately, these compounds were inactive against all four tested human cancer cell lines at the concentration of 128 µg/mL. To the best of our knowledge, compounds 1 and 4 were first reported from the Syzygium genus, while compounds 3 and 5 were isolated from the leaves of Syzygium cumini for the first time.