DETERMINATION OF STRYCHNINE AND BRUCINE BY HPLC  FOR BETTER QUALITY CONTROL OF STRYCHNI SEMEN

Vu Ngan Binh; Pham Thi Thanh Ha; Dang Thi Ngoc Lan; Do Thi Bich Diep; Nguyen Quynh Chi; Do Quyen; Huynh Truc Thanh Ngoc; Nguyen Thi Ngoc Dung; Sysay Palamy; Chiobouaphony Phakeovilay

doi:10.63240/jmm-nimm.2024.6.259

DETERMINATION OF STRYCHNINE AND BRUCINE BY HPLC FOR BETTER QUALITY CONTROL OF STRYCHNI SEMEN

Các tác giả

Vu Ngan Binh

¹

^#

,

Pham Thi Thanh Ha

¹

,

Dang Thi Ngoc Lan

¹

,

Do Thi Bich Diep

¹

,

Nguyen Quynh Chi

¹

,

Do Quyen

¹

,

Huynh Truc Thanh Ngoc

²

,

Nguyen Thi Ngoc Dung

²

,

Sysay Palamy

³

,

Chiobouaphony Phakeovilay

³

¹ Hanoi University of Pharmacy, Vietnam
² culty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
³ Faculty of Pharmacy, University of Health Sciences Laos

DOI:

https://doi.org/10.63240/jmm-nimm.2024.6.259

Từ khóa:

Strychnine, Brucine, Strychni semen, HPLC, Quality control

Tóm tắt

In the 5^th Vietnamese pharmacopoeial monograph for Strychni semen, 19 species of the genus Strychnos are accepted as medicinal material, and the quality of Strychni semen varies significantly. In this study, a high-performance liquid chromatographic (HPLC) method is used to identify and quantify strychnine and brucine in 12 Strychni semen samples collected from different regions in Vietnam and Laos. Based on the alkaloid content in combination with the morphological properties of the analyzed samples, some comments on measures to improve quality control of Strychni semen were suggested for the Vietnam market.

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DETERMINATION OF STRYCHNINE AND BRUCINE BY HPLC FOR BETTER QUALITY CONTROL OF STRYCHNI SEMEN

Các tác giả

DOI:

Từ khóa:

Tóm tắt

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TẠP CHÍ DƯỢC LIỆU (JOURNAL OF MEDICINAL MATERIALS)