AZAPHILONE DERIVATIVES ISOLATED FROM ENDOPHYTIC FUNGUS PENICILLIUM SCLEROTIORUM

Tóm tắt

Endophytic fungi are one of the typical endophytic microbial groups that have recently attracted considerable research interest because of their roles in many aspects. The most special thing is the ability to biosynthesize secondary substances with biological activity, such as antioxidant, anti-microbial, anti-tumor, and anti-inflammatory effects. The endophytic fungal strains were first isolated from Acorus gramineus herbs and identified as Penicillium sclerotiorum by morphological, microscopic, and DNA sequencing based on the modified Sanger method. From the ethyl acetate fraction of the medium extract, six compounds were isolated and identified as peniazaphilones I (1), 11-epi-geumsanol F (2), sclerotioramine (3), epi-isochromophilone III (4), isochromophilone IV (5), and linoleic acid (6). Their structures were determined by means of spectroscopic methods (MS, 1D, and 2D NMR).