CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF ESSENTIAL OILS FROM THE FRUITS OF ZANTHOXYLUM RHETSA GROWN IN THANH HOA PROVINCE, VIETNAM

Tóm tắt

The essential oils from the fresh and dried fruits of Zanthoxylum rhetsa grown in Thanh Hoa province were obtained by hydrodistillation and analyzed by gas chromatography (GC-FID) and gas chromatography/mass spectrometry (GC/MS). The major constituents of fresh fruit essential oil (FF) and dried fruit essential oil (DF) were sabinene, limonene, β-phellandrene, and α-pinene, but their contents in two essential oils were not the same, these values ​​are 51.95%, 7.84%, 7.69%, 3.82% in FF and 32.88%, 20.95%, 9.20%, 4.22% in DF, respectively. In addition, α-phellandrene presents at high content in the DF (10.23%) but it is only the minor component in the FF (0.65%). The EOs were also tested for their cytotoxic and antimicrobial activities. The IC₅₀ values revealed that these two essential oils exhibited a moderate activity against two tested cancer cell lines (MCF-7 and HeLa). For the antimicrobial activities, the FF showed its inhibitory effect on E. coli and B. subtillis (MIC values of 100 µg/mL), while the DF exhibited its potential antimicrobial activity against E. coli, F. oxysporum (MIC values of 100 µg/mL) and weak activity against P. aeruginosa (MIC value of 200 µg/mL).