GLYCOSIDE CONSTITUENTS FROM ABROMA AUGUSTUM AND THEIR IN VITRO ANTIPROLIFERATIVE ACTIVITY

Tóm tắt

Using combined chromatographic experiments, five glycoside derivatives, 1-allyl-3-methoxy-4-[apiofuranosyl(1®2)-glucopyranosyloxybenzene] (1), phenylethyl rutinoside (2), kaempferol 3-O-b-D-glucopyranosyl-(2®1)-b-D-xylopyranoside (3), pinoresinol 4-O-a-L-rhamnopyranosyl (1®2)-b-D-glucopyranoside (4), and (7S*,8R*)-urolignoside (5), were isolated from the methanolic extract of Abroma augustum (L.) L. f. (Malvaceae). Their chemical structures were elucidated on the basis of the 1D (¹H and ¹³C NMR) and 2D (HSQC and HMBC) NMR spectroscopic data in comparison with those published. This is the first report of compounds 1-5 from this species. In addition, compounds 2 and 4 exhibited moderate to weak antiproliferative activity against three human cancer cell lines (MCF-7, HepG2, and SK-LU-1) with IC₅₀ values ranging from 49.38 ± 3.64 to 84.55 ± 6.60 µM.