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25-04-2025

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Cách trích dẫn

PHENOLIC CONSTITUENTS FROM THE LEAVES OF CAMELLIA HAKODAE NINH WITH THEIR α-GLUCOSIDASE INHIBITORY ACTIVITY. (2025). Tạp Chí Dược liệu, 30(2), pp. 92 - 97. https://doi.org/10.63240/jmm-nimm.2025.2.109

PHENOLIC CONSTITUENTS FROM THE LEAVES OF CAMELLIA HAKODAE NINH WITH THEIR α-GLUCOSIDASE INHIBITORY ACTIVITY

Các tác giả

    Pham Hai Yen 1 , Nguyen Thi Cuc 2 , Nguyen Huy Hoang 1 , Pham Van Kiem 1 , Do Thi Ha 3 , Bui Huu Tai 1
  • 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
  • 2 Hanoi Irradiation Centre, Ministry of Science and Technology of Vietnam, Hanoi, Vietnam
  • 3 National Institute of Medicinal Materials (NIMM), Hanoi, 12110, Vietnam

DOI:

https://doi.org/10.63240/jmm-nimm.2025.2.109

Từ khóa:

Camellia hakodae Ninh, Flavonoid glycoside, α-Glucosidase inhibitory activity

Tóm tắt

Six phenolic compounds, including camelliquercetiside D (1), tsubakioside A (2), stachyanthuside A (3), rutin (4), kaempferol 3-rutinoside (5), and kaempferol 3-O-β-D glucopyranoside (6), were isolated from the methanol extract of Camellia hakodae Ninh. Their chemical structures were identified by HR-ESI-MS, 1D and 2D NMR spectra and compared with the published data in the literature. The compounds were screened for their α-glucosidase inhibitory activity. Compounds 1, 2, 4-6 showed significant inhibition with IC50 values of 35.41 ± 0.02, 15.43 ± 0.39, 10.64 ± 0.23, 17.21 ± 0.34, and 19.42 ± 0.25 µM, respectively, compared to that of positive control, acarbose, which showed IC50 value of 47.10 ± 1.40 µM.

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