ANTIHYPERGLYCEMIC ACTIVITY OF GANODERMA NEO-JAPONICUM MUSHROOM IN OBESE/DIABETIC MICE

Tóm tắt

The mushroom Ganoderma neo-japonicum is a new mushroom recently founded in Bu Gia Map National Park on the decomposing bamboo stump (Schizostachyum sp.). It has been studied on culturing, extracting active ingredients and medicinal properties in some countries such as Malaysia, Korea, Thailand, etc. The objective of this study was to investigate the antihyperglycemic effect of biomass extract (MasExt), fruit body extract (FrbExt), fruit body ganoderic acids (FrbGAs) and biomass ganoderic acids (MasGAs) in Swiss albino obese/diabetic mice. The obese mice (were fatted by High-Fat Diet) were induced with type 2 diabetes after dual dose streptozotocin (65mg/kg body weight) 5 days apart. The testing of blood glucose level (GL) in obese/diabetic mice showed that the hypoglycemic activity was present on all four types of active ingredients FrbGAs (↓68.3%GL), MasGAs (↓67.5%GL), MasExt (↓65.9%GL), FrbExt (↓51.6%GL). Thus, G. neo-japonicum mushroom has the hypoglycemic effect in obese mice with type 2 diabetes. In special, MasExt, MasGAs, FrbGAs help mice to better regulating blood glucose level and the amount of insulin in the blood. Addition, MasExt, MasGAs, FrbGAs are not only reduced blood glucose level but also reduced TC, LDL-c level in obese/diabetic mice.