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STUDY ON ANTI-FATIGUE AND IMMUNO-ENHANCEMENT EFFECTS OF THE EXTRACTS FROM PARIETARIA DEBILIS G. FORST. RHIZOME IN MICE
DOI:
https://doi.org/10.63240/jmm-nimm.2024.3.296Từ khóa:
Parietaria debilis Forst. F, Immunosuppression, Immuno - Enhancement, Anti - Fatigue, Cyclophosphamide, MiceTóm tắt
Parietaria debilis G. Forst. is applied to traditional medicine as a medicinal liquor or a medicinal decoction which has effects of liver detoxification, antipyretics, anti - nephritis, anti-arthritis, and so on. The aim of this research is to study the effects of anti-fatigue via Brekhman’s swimming test, and immunostimulation via the immunosuppressive model by cyclophosphamide (at a single dose of 150 mg/kg, i.p) - induced in mice by the aqueous extract (at the oral dose of 0.74g/kg - 1.48g/kg) and 70% ethanol extract (at the oral dose of 0.28g/kg - 0.56g/kg) from P. debilis rhizome. The result showed that aqueous extract and 70% ethanol extracts from P. debilis rhizome at the oral doses markedly increased the mouse swimming times. Besides, the extracts from P. debilis rhizome enhanced the abilities of phagocytes, immune cell-mediated responses (delayed type hypersensitivity), and white blood cells.
