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02-08-2026
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ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF EMBELIA RIBES BURM. F. FRUITS COLLECTED IN SOUTHERN VIETNAM AND ITS CHEMICAL COMPONENTS. (2026). Tạp Chí Dược liệu, 29(2), pp. 92 - 98. https://doi.org/10.63240/jmm-nimm.2024.2.282
ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF EMBELIA RIBES BURM. F. FRUITS COLLECTED IN SOUTHERN VIETNAM AND ITS CHEMICAL COMPONENTS
DOI:
https://doi.org/10.63240/jmm-nimm.2024.2.282Từ khóa:
Embelia ribes, Acetylcholinesterase, EmbelinTóm tắt
Extracts from Embelia ribes Burm. f. fruits in southern Vietnam showed good effects on acetylcholinesterase (AChE) inhibition, with IC50 values of 0.23-0.45 mg/ml. Among them, the dichloromethane fraction showed the potent inhibitory activity. The chemical investigation of this fraction resulted in the isolation of five compounds (1-5). Their chemical structures were identified as kaempferol (1), quercetin (2), hydroxymethylfurfural (3), 5-(8′-Z-heptadecenyl)resorcinol (4), and embelin (5) based on spectral data analysis and literature references. The in vitro AChE inhibitory activity shows embelin may be a principal compound in the most active dichloromethane fraction.
