CHEMICAL COMPOSITION, ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF THE LEAF ESSENTIAL OIL OF KNEMA GLOBULARIA (LAMK.) WARB. FROM THANH HOA, VIETNAM

Tóm tắt

This study reports the chemical composition and, for the first time, evaluates the antimicrobial activity and cytotoxic effects of the leaf essential oil of Knema globularia (Lamk.) Warb. collected in Thanh Hoa Province, Vietnam. The essential oil was obtained by hydrodistillation and analyzed by GC–MS, leading to the identification of 47 compounds representing 97.82% of the total essential oil. The major constituents were β-(E)-caryophyllene (26.24%), α-pinene (18.44%), β-pinene (13.04%), and (3E,6E)-α-farnesene (14.36%). The essential oil showed selective antimicrobial activity against Gram-positive bacteria, with IC₅₀ values of 64.00–80.00 µg/mL, while no significant activity was observed against Gram-negative bacteria or Candida albicans at the tested concentrations. In cytotoxic assays, the essential oil exhibited moderate effects against four human cancer cell lines (KB, HepG2, A549, and MCF-7), with IC₅₀ values ranging from 44.82 to 61.28 µg/mL. These results suggest that the leaf essential oil of K. globularia is a promising natural source for further studies on antimicrobial and anticancer agents.