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ANTIMICROBIAL DIKETOPIPERAZINE ALKALOIDS AND INDOLE DERIVATIVES FROM THE MARINE-DERIVED FUNGUS PENICILLIUM sp. M874
DOI:
https://doi.org/10.63240/jmm-nimm.2025.5.165Từ khóa:
Penicillium, Diketopiperazine alkaloids, Indoles, Secondary metabolites, Marine fungiTóm tắt
From the solid-fermented product of the marine sediment-derived Penicillium sp. M874 collected in Ninh Thuan, Vietnam, eight secondary metabolites, including four diketopiperazine alkaloids, 6-methoxyspirotryprostatin B (1), tryprostatin B (2), 12,13-dihydroxy-fumitremorgin C (3), bis(dethio)bis(methylthio)gliotoxin (4), and four indoles, 1H-indole-3-ethanol (5), N-acetyltryptamine (6), 3-formylindole (7), and 3-hydroxyacetylindole (8) were isolated and structurally elucidated. The structures of these compounds were determined by MS and NMR spectra analyses and by comparison with literature data. Six compounds, 1-5 and 7, displayed antimicrobial effects against at least one of the tested reference microorganisms, with MIC values ranging from 8 to 256 μg/mL.
